<scp>MicroRNA</scp> ?mediated extracellular matrix remodeling in squamous cell carcinoma of the oral cavity

BACKGROUND We evaluated microRNAs and extracellular matrix component profiles in squamous cell carcinoma of the oral cavity (OSCC) comparison to healthy mucosa. METHODS Retrospective study investigating 64 related oncogenic process constituents matrix. also performed immunohistochemical assays for molecules involved same biological processes. RESULTS High expression miR-21-5p (p?<?0.001) miR-106-5p low miR-320a (p = 0.001) miR-222-3p were predictors malignancy. Individually, exhibited best statistical performance (area under curve 0.972; 95% confidence interval: 0.911-1.000) differentiation between tumor tissue Moreover, sample showed increased MMP-2, MMP-9, ?-laminin, ?-laminin tumor-related fibroblasts lower continuity type IV collagen basement membrane. CONCLUSION The present demonstrates effects on carcinogenesis OSCC as well intense modification microenvironment.